CENTER FOR METABOLISM AND MITOCHONDRIAL MEDICINE
   

The 7th Regional

TRANSLATIONAL RESEARCH ON
MITOCHONDRIA, METABOLISM, AGING, AND
DISEASE SYMPOSIUM (TRiMAD)

OCTOBER 5 & 6, 2017

 
 

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Agenda

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Friday, October 6, 2017


7:45am

Breakfast - University Club Ballroom B

 

 

8:15-10:15am

SYMPOSIUM 4: MODEL ORGANISMS, MITOCHONDRIAL SIGNALING, PROTEOMICS, and METABOLOMICS
Session Chair: Nam Vo, PhD (UPitt)

8:15-8:40

Aditi Gurkur, PhD (UPitt) - "DNA damage induced nuclear-mitochondrial communicaion in aging"

8:40-9:05

Iain Scott, PhD (UPitt) - "Mitochondrial Acetylation and Regulation of Metabolism"

9:05-9:30

Arjumand Ghazi, PhD (UPitt) - "Balancing Lipogenesis and Lipolysis for Longevity"

9:30-9:55

Erin Seifert, PhD (Jefferson) - "Adaptive and maladaptive responses to depletion of the mitochondrial phosphate carrier"

9:55-10:15

Abstract Talk: Gary THomas, PhD (UPitt) - "Allosteric Modulation of SIRT1 by PACS-2 and DBC1 regulatory hub"

Abstract Talk: Shilpy Joshi, PhD (Rutgers Cancer Institute) - "Dual role of mitochondria in tumor initiation and progression"

 

 

10:15-10:45am

COFFEE BREAK

 

 

10:45-12:45

SYMPOSIUM 5: MITOCHONDRIA, DNA, and METABOLISM
Session Chair: Fabrisia Ambrosio, PhD, MPT (UPitt)

10:45-11:10

Michael Palladino, PhD (UPitt) - "Developing novel treatments for mitochondrial disease"

11:10-11:35

Brett Kaufman, PhD (UPitt) - "G-quadruplexes structures cause mitochondrial dysfunction"

11:35-12:00

Yusuke Sekine, PhD (NIH/NHLBI) - "CRISPR based approaches to understand metabolism"

12:00-12:20

Kateryna Makova, PhD (Penn State) - "Transmission of Mitochondrial DNA Heteroplasmies Across Multi-Generation Pedigrees"

12:20-12:40

Abstract Talk: Paul Brookes, PhD (U of Rochester) - "Direct stimulation of glycolysis accounts for cellular metabolic benefits of the NAD+ precursor nicotinamide mononucleotide (NMN)"

Abstract Talk: Vincent Miller, PhD (Ohio State U) - "Effects of ketogenic diet with exercise training on mitochondrial substrate oxidation in human skeletal muscle"

 

 

12:45-2:00pm

LUNCH / POSTERS / NETWORKING TIME

 

 

2:00-4:00pm

SYMPOSIUM 6: MITOCHONDRIAL DYNAMICS & QUALITY CONTROL
Session Chair: Paul Brookes, PhD (U of Rochester)

2:00-2:25

Charleen Chu, MD, PhD (UPitt) - "Mitochondrial calcium dysregulation in neurodegeneration"

2:25-2:50

Michael Jurczak, PhD (UPitt) - "Divergent metabolic phenotypes in germline and conditional PARK2 knockout mice"

2:50-3:15

John Elrod, PhD (Temple) - "Mitochondrial Calcium Signaling in Bioenergetics and Fibroblast Transdifferentiation"

3:15-3:40

Cynthia McMurray, PhD (Lawrence Berkeley National Lab) - "Region-specific neuronal toxicity the HdHQ(150/150) mice arises by metabolic compensation for a complex II defect in astroglial cells"

3:40-4:00

Abstract Talk: Brian Martin, BS (UPitt) - "Relaxin reverses age induced inflammation with distinct sex differences"

Abstract Talk: Yalikun Suofo, PhD (UPitt) - "Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release"

 

 

4:00-4:15pm

BREAK

 

 

4:30-5:30pm

KEYNOTE LECTURE - Raul Mostoslavsky, MD, PhD (Harvard Medical School) -
"Linking Metabolism to Epigenetics and Cancer: SIRT6 provides new clues"

   

5:45pm

MEETING CLOSE