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Vascular Medicine Institute

VMI

Tamir Kanias, Ph.D.

Tamir Kanias

Research Assistant Professor of Medicine
Pulmonary, Allergy and Critical Care Medicine

E1200-22B BST
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-624-5004
Fax: 412-648-3046
Email:tak77@pitt.edu

Gladwin Lab

Bio

Dr. Kanias earned his undergraduate degree in Biological Sciences from Tel Aviv University in 1998,  and an M.Sc in Agricultural Sciences from the Hebrew University in 2002. Between 2003-2005, he worked as a staff scientist in the field of cryobiology where he introduced the use of green tea antioxidants as cellular protectants against freezing and desiccation injuries. After moving to Canada in 2005, he earned his PhD in Medical Sciences in 2010 at the University of Alberta, Canada, with the thesis “Evaluation of desiccation-induced oxidative injury in human red blood cells”. He joined the Gladwin lab at the University of Pittsburgh in October, 2010.

Research Interests

Hemolysis is a significant risk factor limiting the duration of storage and the quality of red blood cell products. Intravascular hemolysis can compromise regulation of blood flow through hemoglobin-mediated nitric oxide scavenging leading to endothelial and pulmonary dysfunctions. Other symptoms are related to the toxic effects of hemoglobin denatured products, such as hemin, capable of intensifying inflammation response of vessel endothelial cells, and promoting atherosclerosis through the oxidation of low-density lipoproteins.
Studies have shown that RBCs donated by premenopausal women exhibit higher resistance to mechanical hemolysis compared with male donors. Similarly, red blood cells from males with sickle cell disease are significantly more susceptible to hemolysis compared with female patients. In inbred mice, strains differ in their response to oxidative hemolysis. Dr. Kanias’ research focuses on the molecular mechanisms of red blood cell hemolysis. The study examines gender and genetic variation in the propensity of red blood cells to hemolyze under diverse stressors. 

Key Publications

Kanias T, Acker JP. (2010) Mechanism of hemoglobin-induced cellular injury in desiccated red blood cells. Free Radic Biol Med. 49(4):539-47.

Kanias T, Acker JP. (2010) Biopreservation of red blood cells--the struggle with hemoglobin oxidation. FEBS J. 277(2):343-56.

Kanias T, Acker JP. (2009) Trehalose loading into red blood cells is accompanied with hemoglobin oxidation and membrane lipid peroxidation. Cryobiology. 58(2):232-9.

Kanias T, Wong K, Acker JP. (2007) Determination of lipid peroxidation in dessicated red blood cells. Cell Preservation Technology. 5(3):165-74.

Kanias T, Acker JP. (2006) Mammalian Cell Dessication: Facing the Challenges. Cell Preservation Technology. 4(4):253-77.

Pubmed link

 

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