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Vascular Medicine Institute

VMI

Margaret Ragni, M.D.

Ragni

Professor of Medicine
Division of Hematology/Oncology
Director, Hemophilia Center of Western PA

3636 Boulevard of the Allies, 2nd floor
Pittsburgh, PA 15213

Phone: (412) 209-7288
Fax: (412) 209-7281
Email: ragni@pitt.edu

Bio

Dr. Ragni is a Professor of Medicine, Department of Medicine, Division of Hematology/ Oncology, University of Pittsburgh, and Director, Hemophilia Center of Western Pennsylvania. She received her M.D. degree from the University of Pittsburgh School of Medicine in 1975 and M.P.H. in 1993 from the Graduate School of Public Health. She completed her medical residency in 1978 and a fellowship in Hematology/Oncology in 1981 at the University of Pittsburgh Medical Center, and a fellowship in Coagulation/Blood Bank at Central Blood Bank, Pittsburgh in 1982. She is active in clinical translational research and in mentoring fellows, residents, and students, and is funded by federal research grants from NHLBI and NIAID. She has authored over 200 peer-reviewed publications in the area of hemophilia and von Willebrand disease, and in transfusion-related hepatitis C and HIV/HCV co-infection. She is the recipient of the Kenneth Brinkhous Award for Excellence in Clinical Research by the National Hemophilia Foundation, 1998; and the Kenneth E. Schuit Award, Dean’s Award for Master Educator by the University of Pittsburgh, in 1998. She serves on the NHLBI Hemostasis and Thrombosis Study Section; the American Society of Hematology Development Committee; is past editor of the ASH News Daily, on the Executive Board of the Hemophilia &Thrombosis Research Society of North America, and as a member of the National Hemophilia Foundation Medical and Scientific Advisory Committee. She is a member of NHLBI Hemostasis & Thrombosis study section, and serves as Co-Chair, Hemophilia & Von Willebrand Subcommittee of the NHLBI State-of-the-Art Symposium to determine national hemostasis research priorities.

Clinical Interests

  1. Clinical diagnosis and management of congenital bleeding disorders
  2. Clinical diagnosis and management of congenital thrombotic disorders
  3. Complications of hemophilia: inhibitor formation, HIV/HCV coinfection
  4. Clinical aspects and management of bleeding disorders in women: hemophilia carriers, von Willebrand disease, factor XI deficiency

Research Interests

  1. HCV/HIV Co-Infection, Liver Disease Progression
  2. Liver, Kidney Transplantation in HIV Infection
  3. Bleeding disorders in Women
  4. Von Willebrand Disease: Novel therapeutics:  IL-11
  5. Von Willebrand Disease: Phenotype, genotype
  6. Complications of HIV Infection in Hemophilia
  7. Gene Therapy for Hemophilia
  8. Thrombosis, Congenital Thrombophilia, Anticoagulation
  9. Dendritic Cells, Immune Tolerance and Inhibitors in Hemophilia Mouse Model
  10. Bleeding Disorders and Ischemic Heart Disease Mortality

Key Publications

Ragni MV, Belle SH.  Impact of human immunodeficiency virus (HIV) on progression to end-stage liver disease in individuals with hemophilia and hepatitis C. J Infect Dis 2001;183; 1112-1115.

Ragni MV, Belle SH, Im K, Neff G, Roland M, Stock P, Heaton N, Humar A, Fung JF. Survival in HIV-infected liver transplant recipients. J Infect Dis 2003; 188: 1412-1420.

Mingozzi F, Maus MV, Hui DJ, Sabatino DE, Murphy SL, Rasko JEJ, Ragni MV, Manno CS, Sommer J, Jiang H, Pierce GF, Ertl HCJ, High KA. CD8+ T-cell responses to adeno-associated virus capsid in humans. Nature Med 2007; 13: 419-422.

Ragni MV, Jankowitz RC, Nichols TM. A phase II prospective open-label escalating dose trial of interleukin-11 (rhIl-11, Neumega®) in mild von Willebrand disease. Haemophilia 2008; 14: 968-977

Ragni MV, Schillo R, Nalesnik MA, Dang Q.  HAART improves ESLD-free survival in HIV-HCV co-infection. Haemophilia 2009; 15: 552-558.

Ragni MV, Wu W, Liang X, Cortese-Hassett A, Lu L. Factor VIII-pulsed tolerogenic dendritic cells reduce F.VIII inhibitor formation in the murine hemophilia A model. Exp Hematol 2009; in press 10.1016/j.exphem.2009.02.011

Pubmed link

Textbooks

Ragni, MV, Kessler CM, Lozier JN. Clinical Aspects and Therapy of Hemophilia. In:   Hematology: Basic Principles and Practice, Fifth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, HJ Cohen, LE Silberstein, P McGlave, eds), Elsevier Churchill Livingstone, Philadelphia, 2009; 1911-1930

Ragni MV.  The Hemophilias: Factor VIII and FIX Deficiencies, Chapter, In Clinical Hematology, Young NS, Gerson SL, High KA, eds., Elsevier Inc., Philadelphia, PA 2006:814-829.

Ragni MV.  Transfusion Transmitted Disease: Hepatitis C Virus Infection & Liver Transplantation, Chapter, In Textbook of Haemophilia, Lee CA, Berntorp E, Hoots K, ed, Blackwell Publishing, Ltd., Malden, MA, 2005; pp 207-13.

Schlesinger KW, Rinder HM, Ragni MV.  Women with Bleeding Disorders, Chapter, In Menorrhagia and Women’s Health, American College of Physicians/American Society of Internal Medicine Women’s Health Book Series, Philadelphia, 2006, pp. 171-195.

News

Dr. Ragni was a speaker at the American Society of Hematology 2006 Special Symposium, focusing on "Bleeding Disorders in Women: Another Crisis in Hematology."

Dr. Ragni has adapted show tunes and words as tributes to colleagues:

  • 6/7/2003, For Gala Honoring Bruce Evatt, MD, Director CDC Blood Diseases Division
    Model of a Modern Research-General,” adapted from “Model of a Modern Major-General”
    By Gilbert & Sullivan. Performers: Steve Humes, Sarah Steele, accompanist: Margaret Ragni, MD
  • 7/31/2005, In Honor of Steven Humes, Director, Research, National Hemophilia Foundation
    "Steven and the Amazing Technicolor Labcoat,” adapted from “Joseph and the Amazing Technicolor Dreamcoat,” by Andrew Lloyd Weber and Tim Rice. Performers: Sally Crudder, RN, Andra
    James MD, accompanist:  Margaret Ragni, MD

Links

Dr. Ragni serves on the Medical & Scientific Advisory Committee, NHF

Dr. Ragni was the Editor for ASH News Daily in 2007

Dr. Ragni is a member of the National Hemophilia Foundation, Western Pennsylvania Chapter

 

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