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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Laboratories

AL GHOULEH LAB

Dr. Al Ghouleh’s lab is focused on the study of pulmonary hypertension, with a major focus on defining the mechanisms that underlie right ventricular phenotypic changes in this disease.

Imad al Ghouleh, PhD
Principal Investigator

 

 

BULLOCK LAB

The Bullock Lab is interested in disorders of blood cell production and function in human hematologic diseases with a major focus on the influence of iron deficiency/sequestration on erythropoiesis in a variety of anemias. A related area of interest is the role of mitochondrial metabolism in erythropoiesis and megakaryopoiesis.

Grant Bullock, MD, PhD

Grant C. Bullock, MD, PhD
Principal Investigator

 

 

BRUEMMER LAB

Dr. Bruemmer’s current research focuses on transcriptional mechanisms by which common cardiovascular risk factors including diabetes, obesity, and inflammation activate vascular gene expression programs leading the development of atherosclerosis and restenosis.

Dennis Bruemmer, MD, PhD
Principal Investigator

 

 

CHAN LAB

Dr Chan's lab studies the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH). Ongoing projects include: 1) Defining the network biology of non-coding RNAs in pulmonary hypertension, 2) Studying the molecular regulation of mitochondrial metabolism by microRNAs, and 3) Defining the regulation of circulating microRNAs in hypoxia and exercise.

Stephen Y. Chan, MD, PhD
Principal Investigator

 

 

DUTTA LAB

Dr. Dutta's laboratory studies 1) the role of inflammation in cardiovascular diseases, and 2) activation of hematopoietic stem cells after myocardial infarction.

Partha Dutta, DVM, PhD
Principal Investigator

 

 

GLADWIN LAB

Dr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease. 

Mark Gladwin, MD

Mark T. Gladwin, MD
Principal Investigator

 

 

GONCHAROVA LAB

Dr. Goncharova’s research interests have focused on the signaling mechanisms regulating cellular energy metabolism, proliferation, motility and survival as it relates to the pathogenesis of pulmonary arterial hypertension (PAH) and pulmonary lymphangioleiomyomatosis (LAM).

Elena A. Goncharova, PhD

Elena A. Goncharova, PhD
Principal Investigator

 

 

ISENBERG LAB

The Isenberg Lab studies the role matrix-cellular proteins play in controlling blood flow and tissue survival. Dr. Isenberg is particularly interested in the thrombospondin-1-CD47 signaling nexus and the role it has in modulating the canonical nitric oxide (NO) pathway.

Jeff Isenberg, MD, MPH

Jeffrey S. Isenberg, MD, MPH
Principal Investigator

 

 

KATO LAB

The Kato lab investigates molecular mechanisms and clinical-translational aspects of sickle cell disease.  We are particularly interested in altered signaling in erythroid progenitor cells induced by heme-bound iron, including stimulation of placenta growth factor and consequent development of pulmonary hypertension.  We also study new treatments for sickle cell disease, and we develop new platforms and methods to study sickle cell disease.

Greg Kato, MD

Gregory J. Kato, MD
Principal Investigator

 

 

KAUFMAN LAB

The major research goals of the Kaufman Lab are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease.

brett kaufman

Brett A. Kaufman, PhD
Principal Investigator

 

 

KIM LAB

The Multi-modality Biomedical Ultrasound Imaging Lab led by Dr. Kang Kim develops ultrasound-based technologies that can non-invasively image structural, mechanical, compositional, and functional features of biological tissues.

kang kim

Kang Kim, MD
Principal Investigator

 

 

MORA LAB

The overall goal of Dr. Mora's laboratory is to understand the pathogenesis of Idiopathic Pulmonary Fibrosis.

Ana Mora, MD

Ana L. Mora, MD
Principal Investigator

 

 

NAGARAJAN LAB

Dr. Nagarajan's current projects include: 1) investigating the role of auto-antibodies, specifically antibody against oxLDL in the initiation and progression of atherosclerosis and the role of the immune system in pathophysiology of atherosclerosis, 2) investigating how dietary factors modulate the immune system to prevent chronic inflammatory diseases including atherosclerosis, and 3) studying the causal link between genital Chlamydia induced inflammatory responses promoting atherosclerosis.

Shan Nagarajan, PhD

Shanmugam, Nagarajan, PhD
Principal Investigator

 

 

NOVELLI LAB

The Novelli Lab focuses on elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in Sickle Cell Disease. 

Enrico Novelli, MD, MS

Enrico M. Novelli, MD, MS
Principal Investigator

 

 

OFORI-ACQUAH LAB

The Ofori-Acquah laboratory studies the role and mechanism of hemin in endothelial barrier regulation and in the pathobiology of sickle cell disease.

Solomon Ofori-Acquah, PhD

Solomon F. Ofori-Acquah, PhD
Principal Investigator

 

 

PAGANO LAB

The overall goal of Dr. Pagano's laboratory is to investigate the role of NADPH oxidase in normal cellular function as well as under a variety of pathophysiological conditions.

Patrick Pagano, PhD

Patrick J. Pagano, PhD
Principal Investigator

 

 

SABA LAB

Dr. Saba's research broadly focusses on examining patient outcomes in patients suffering from arrhythmic conditions. More specifically, his laboratory has concentrated its efforts over the past few years on studying the causes of racial and gender disparities in the delivery of defibrillator therapy and on evaluating interventions to reduce and eliminate these disparities.

samir saba

Samir Saba, MD
Principal Investigator

 

 

SALAMA LAB

A central goal of Dr. Salama's laboratory is to elucidate the mechanisms responsible for the initiation and termination of cardiac arrhythmias.

guy salama

Guy Salama, PhD
Principal Investigator

 

 

SCOTT LAB

Dr. Scott’s work focuses on the intrinsic mechanisms that regulate mitochondrial protein acetylation, and how this fundamental alteration affects organelle function at the cellular and tissue level.

Iain Scott, PhD

Iain Scott, PhD
Principal Investigator

 

 

SHIVA LAB

The overarching goal of the Shiva laboratory is to determine the molecular mechanisms by which reactive oxygen and nitrogen species regulate mitochondrial function and mediate signaling through the mitochondria, particularly in conditions of both physiological hypoxia and pathological ischemia/reperfusion.

Sruti Shiva, PhD

Sruti S. Shiva, PhD
Principal Investigator

 

 

SIMON LAB

Dr. Simon’s current research interests include the study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure.

Marc Simon

Marc Simon, MD, MS
Principal Investigator

 

 

ST. HILAIRE LAB

Dr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts.

Cynthia St. Hilaire, PhD
Principal Investigator

 

 

 

STRAUB LAB

The Straub laboratory investigates redox-controlled cell signaling mechanisms that regulate endothelial and smooth muscle biology of the microcirculation in the setting of both physiology and cardiovascular disease.

Adam Straub, PhD

Adam C. Straub, PhD
Principal Investigator

 

 

SUNDD LAB

Dr. Sundd’s research focuses on the mechanisms of leukocyte rolling and arrest during inflammation; the role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome; and identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood. 

Prithu Sundd, PhD

Prithu Sundd, PhD
Principal Investigator

 

 

VILLANUEVA LAB

The Center for Ultrasound Molecular Imaging and Therapeutics is a multidisciplinary translational research facility espousing the philosophy that moving technologies from pre-clinical status to the bedside requires strong traditional science and engineering, married to strong entrepreneurship.

liza villanueva

Liza Villanueva, MD
Principal Investigator
To view personnel listed alphabetically, visit the PEOPLE page.