Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Marc A. Simon, MD, MS, FACC


Marc A Simon MD


Marc Simon, MD, MS, FACC

Associate Professor of Medicine, Bioengineering, and Clinical Translational Science

Director, Heart Failure Research / Clinical Hemodynamics Core Facility

S-555 Scaife Hall
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-802-3131
Lab Phone: 412-648-7457
Email: simonma@upmc.edu

Assistant: Tina Furlano
Email: furlanot@upmc.edu

UPMC Profile

Simon Lab



BS, University of Pennsylvania, 1994

MD, University of Maryland, 1998

MS in Bioengineering, University of Pittsburgh, 2007


Internal Medicine, University of Colorado, 2001

Cardiology, University of Pittsburgh, 2004

Heart Failure and Transplant Cardiology, University of Pittsburgh, 2005

Areas of Specialization

Right ventricular function

Mechanical circulatory support and artificial heart

Heart failure

Pulmonary Hypertension

Research Interests

Dr. Simon’s current research interests include the study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure.


Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS. (2014) Structural and mechanical adaptations of right ventricular free wall myocardium to pulmonary hypertension-induced pressure overload. Annals of Biomedical Engineering. Accepted, Aug 11, 2014.

Vanderpool RR, Pinsky MR, Naeije R, Deible C, Kosaraju V, Bunner C, Mathier MA, Lacomis J, Champion HC, Simon MA. (2014) RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart. Accepted, Aug 11, 2014.

Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A. (2014) Isolated Right Ventricular Dysfunction in Patients with Human Immunodeficiency Virus. Journal of Cardiac Failure. 20(6):414-21.

Wu J, Simon MA, Brigham JC. (2014) A comparative analysis of global shape analysis methods for the assessment of the human right ventricle. Computer Methods in Biomechanics and Biomedical Emgineering: Imaging & Visualization. doi: 10.1080/21681163.2014.941442

Wu J, Brigham KG, Simon MA, Brigham JC. (2014) An implementation of independent component analysis for 3D statistical shape analysis. Biomedical Signal Processing and Control. 13:345-56.

Simon MA. Assessment and treatment of right ventricular failure. (2013) Nature Reviews Cardiology. 10:204-18.

Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. (2012) A murine experimental model for the mechanical behavior of viable right-ventricular myocardium. J Physiol. 590(18):4571-84.

Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan III J, McNamara DM. (2010) Left ventricular remodeling and myocardial recovery on mechanical circulatory support. J Card Fail. 16(2):99-105.

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Lormos RL. (2010) Early adverse events as predictors of one-year mortality during mechanical circulatory support. J Heart Lung Transplant. 29(9):981-8.

Simon MA, Kliner D, Girod JP, Moguillansky D, Villanueva FS, Pacella JJ. (2010) Detection of elevated right arterial pressure using a simple bedside ultrasound measure. Am Heart J. 159(3):421-7.

Bhattacharya B, Abebe K, Simon MA, Saba S, Adelstein E. (2010) Role of cardia resynchronization in end-stage heart failure patients requiring inotrope therapy. J Card Fail. 16(12):931-7.

Nair PK, Kormos RL, Teuteberg JJ, Mathier MA, Bermudez CA, Toyoda Y, Dew MA, Simon MA. (2010) Pulsatile left ventricular assist device support as a bridge to decision in patients with end-stage heart failure complicated by pulmonary hypertension. J Heart Lung Transplant. 29(2):201-8.

Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, Lopez-Candales A. (2009) Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. Congest Heart Fail. 15(6):271-6.

Simon MA, Deible C, Mathier MA, Lacomis J, Goitein O, Shroff SG, Pinsky MR. (2009) Phenotyping the right ventricle in patients with pulmonary hypertension. Clinical and Translational Science. 2(4):294-299.

Johnson L, Simon MA, Pinsky MR, Shroff SG. (2009) Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function. PACE. 32(2):224-33.

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Kay J, Siegenthaler MP, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL. (2009) Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation. Annals of Thoracic Society. 88(4):1162-70.

Rajagopalan N, Simon MA, Edelman K, Mathier MA, Lopez-Candales A. (2009) Identifying left ventricular dysfunction in pulmonary hypertension. Congest Heart Fail. 15(5):218-21.

Pubmed link