AL GHOULEH LAB

Dr. Al Ghouleh’s lab is focused on the study of pulmonary hypertension, with a major focus on defining the mechanisms that underlie right ventricular phenotypic changes in this disease.

BECKER LAB

The Becker Lab studies genetic and acquired cardiomyopathies in an effort to identify novel methods to prevent and treat hypertrophic cardiomyopathy and heart failure. We utilize a variety of experimental systems which include mouse, zebrafish, iPSC-cardiomyocytes and human tissue samples.

CHAN LAB

Dr Chan's lab studies the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH). Ongoing projects include: 1) Defining the network biology of non-coding RNAs in pulmonary hypertension, 2) Studying the molecular regulation of mitochondrial metabolism by microRNAs, and 3) Defining the regulation of circulating microRNAs in hypoxia and exercise.

DUTTA LAB

Dr. Dutta's laboratory studies 1) the role of inflammation in cardiovascular diseases, and 2) activation of hematopoietic stem cells after myocardial infarction.

GLADWIN LAB

Dr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease. 

GOMEZ LAB

The Gomez lab is focused on studying the functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis.

GONCHAROVA LAB

Dr. Goncharova’s research interests have focused on the signaling mechanisms regulating cellular energy metabolism, proliferation, motility and survival as it relates to the pathogenesis of pulmonary arterial hypertension (PAH) and pulmonary lymphangioleiomyomatosis (LAM).

KAUFMAN LAB

The major research goals of the Kaufman Lab are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease.

KIM LAB

The Multi-modality Biomedical Ultrasound Imaging Lab led by Dr. Kang Kim develops ultrasound-based technologies that can non-invasively image structural, mechanical, compositional, and functional features of biological tissues.

MORA LAB

The overall goal of Dr. Mora's laboratory is to understand the pathogenesis of Idiopathic Pulmonary Fibrosis.

NOVELLI LAB

The Novelli Lab focuses on elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in Sickle Cell Disease. 

OFORI-ACQUAH LAB

The Ofori-Acquah laboratory studies the role and mechanism of hemin in endothelial barrier regulation and in the pathobiology of sickle cell disease.

PAGANO LAB

The overall goal of Dr. Pagano's laboratory is to investigate the role of NADPH oxidase in normal cellular function as well as under a variety of pathophysiological conditions.

SABA LAB

Dr. Saba's research broadly focusses on examining patient outcomes in patients suffering from arrhythmic conditions. More specifically, his laboratory has concentrated its efforts over the past few years on studying the causes of racial and gender disparities in the delivery of defibrillator therapy and on evaluating interventions to reduce and eliminate these disparities.

Samir Saba, MD
Principal Investigator

SALAMA LAB

A central goal of Dr. Salama's laboratory is to elucidate the mechanisms responsible for the initiation and termination of cardiac arrhythmias.

Guy Salama, PhD
Principal Investigator

SCOTT LAB

Dr. Scott’s work focuses on the intrinsic mechanisms that regulate mitochondrial protein acetylation, and how this fundamental alteration affects organelle function at the cellular and tissue level.

Iain Scott, PhD
Principal Investigator

SHIVA LAB

The overarching goal of the Shiva laboratory is to determine the molecular mechanisms by which reactive oxygen and nitrogen species regulate mitochondrial function and mediate signaling through the mitochondria, particularly in conditions of both physiological hypoxia and pathological ischemia/reperfusion.

SIMON LAB

Dr. Simon’s current research interests include the study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure.

Marc Simon, MD, MS
Principal Investigator

ST. HILAIRE LAB

Dr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts.

Cynthia St. Hilaire, PhD
Principal Investigator

STRAUB LAB

The Straub laboratory investigates redox-controlled cell signaling mechanisms that regulate endothelial and smooth muscle biology of the microcirculation in the setting of both physiology and cardiovascular disease.

SUNDD LAB

Dr. Sundd’s research focuses on the mechanisms of leukocyte rolling and arrest during inflammation; the role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome; and identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood. 

TAVAKOLI LAB

Dr. Tavakoli's research interest is development of novel molecular and metabolic imaging strategies for early detection and risk stratification of cardiovascular and pulmonary diseases using high-resolution SPECT and PET.

VILLANUEVA LAB

The Center for Ultrasound Molecular Imaging and Therapeutics is a multidisciplinary translational research facility espousing the philosophy that moving technologies from pre-clinical status to the bedside requires strong traditional science and engineering, married to strong entrepreneurship.