Laboratories
AL GHOULEH LABDr. Al Ghouleh’s lab is focused on the study of pulmonary hypertension, with a major focus on defining the mechanisms that underlie right ventricular phenotypic changes in this disease. |
Principal Investigator |
BECKER LABThe Becker Lab studies genetic and acquired cardiomyopathies in an effort to identify novel methods to prevent and treat hypertrophic cardiomyopathy and heart failure. We utilize a variety of experimental systems which include mouse, zebrafish, iPSC-cardiomyocytes and human tissue samples. |
Principal Investigator |
CHAN LABDr Chan's lab studies the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH). Ongoing projects include: 1) Defining the network biology of non-coding RNAs in pulmonary hypertension, 2) Studying the molecular regulation of mitochondrial metabolism by microRNAs, and 3) Defining the regulation of circulating microRNAs in hypoxia and exercise. |
Principal Investigator |
DUTTA LABDr. Dutta's laboratory studies 1) the role of inflammation in cardiovascular diseases, and 2) activation of hematopoietic stem cells after myocardial infarction. |
Principal Investigator |
GLADWIN LABDr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease. |
Principal Investigator |
GOMEZ LABThe Gomez lab is focused on studying the functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis. |
Principal Investigator |
KAUFMAN LABThe major research goals of the Kaufman Lab are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease. |
Principal Investigator |
KIM LABThe Multi-modality Biomedical Ultrasound Imaging Lab led by Dr. Kang Kim develops ultrasound-based technologies that can non-invasively image structural, mechanical, compositional, and functional features of biological tissues. |
Principal Investigator |
MORA LABThe overall goal of Dr. Mora's laboratory is to understand the pathogenesis of Idiopathic Pulmonary Fibrosis. |
Principal Investigator |
NOVELLI LABThe Novelli Lab focuses on elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in Sickle Cell Disease. |
Principal Investigator |
OFORI-ACQUAH LABThe Ofori-Acquah laboratory studies the role and mechanism of hemin in endothelial barrier regulation and in the pathobiology of sickle cell disease. |
Principal Investigator |
PAGANO LABThe overall goal of Dr. Pagano's laboratory is to investigate the role of NADPH oxidase in normal cellular function as well as under a variety of pathophysiological conditions. |
Principal Investigator |
SABA LABDr. Saba's research broadly focusses on examining patient outcomes in patients suffering from arrhythmic conditions. More specifically, his laboratory has concentrated its efforts over the past few years on studying the causes of racial and gender disparities in the delivery of defibrillator therapy and on evaluating interventions to reduce and eliminate these disparities. |
Samir Saba, MD |
SALAMA LABA central goal of Dr. Salama's laboratory is to elucidate the mechanisms responsible for the initiation and termination of cardiac arrhythmias. |
Guy Salama, PhD |
SCOTT LABDr. Scott’s work focuses on the intrinsic mechanisms that regulate mitochondrial protein acetylation, and how this fundamental alteration affects organelle function at the cellular and tissue level. |
Iain Scott, PhD |
SHIVA LABThe overarching goal of the Shiva laboratory is to determine the molecular mechanisms by which reactive oxygen and nitrogen species regulate mitochondrial function and mediate signaling through the mitochondria, particularly in conditions of both physiological hypoxia and pathological ischemia/reperfusion. |
Principal Investigator |
SIMON LABDr. Simon’s current research interests include the study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure. |
Marc Simon, MD, MS |
ST. HILAIRE LABDr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts. |
Cynthia St. Hilaire, PhD, FAHA
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STRAUB LABThe Straub laboratory investigates redox-controlled cell signaling mechanisms that regulate endothelial and smooth muscle biology of the microcirculation in the setting of both physiology and cardiovascular disease. |
Principal Investigator |
SUNDD LABDr. Sundd’s research focuses on the mechanisms of leukocyte rolling and arrest during inflammation; the role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome; and identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood. |
Principal Investigator |
TAVAKOLI LABDr. Tavakoli's research interest is development of novel molecular and metabolic imaging strategies for early detection and risk stratification of cardiovascular and pulmonary diseases using high-resolution SPECT and PET. |
Principal Investigator |
VILLANUEVA LABThe Center for Ultrasound Molecular Imaging and Therapeutics is a multidisciplinary translational research facility espousing the philosophy that moving technologies from pre-clinical status to the bedside requires strong traditional science and engineering, married to strong entrepreneurship. |
Principal Investigator |
To view personnel listed alphabetically, visit the PEOPLE page. |